CAS No.:94-75-7
Name: 2,4-Dichlorophenoxyacetic acid
Details Introduction
TOXICITY DATA with REFERENCE:
1. |
skn-rbt 500 mg/24H MLD |
28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,279. | ||
2. |
eye-rbt 750 μg/24H SEV |
28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,279. | ||
3. |
sce-hmn:lym 10 mg/L |
JOHEA8 Journal of Heredity. 73 (1982),224. | ||
4. |
dni-ham:ovr 1 mmol/L |
TOLED5 Toxicology Letters. 29 (1985),137. | ||
5. |
orl-rat TDLo:500 mg/kg (female 6-15D post):REP |
FCTXAV Food and Cosmetics Toxicology. 9 (1971),801. | ||
6. |
orl-mus TDLo:707 mg/kg (female 11-14D post):TER |
AECTCV Archives of Environmental Contamination and Toxicology. 6 (1977),33. | ||
7. |
orl-man TDLo:2 g/kg:BAH,PUL |
ARTODN Archives of Toxicology. 66 (1992),518. | ||
8. |
orl-man TDLo:5714 mg/kg:BAH,CVS |
ARTODN Archives of Toxicology. 66 (1992),518. | ||
9. |
orl-hmn LDLo:80 mg/kg:GIT,CNS |
ARPAAQ Archives of Pathology. 94 (1972),270. | ||
10. |
orl-ma |
Consensus Reports:IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 156.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 41 (1986),p. 357.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 (1977),p. 111.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 (1977),p. 111.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. Community Right-To-Know List.
SAFETY PROFILE:
Suspected human carcinogen. Experimental teratogenic and reproductive effects. Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. Human systemic effects by ingestion: change in heart rate, coma, convulsions, nausea or vomiting, respiratory depression, somnolence. Can cause liver and kidney injury. A skin and severe eye irritant. Human mutation data reported.
Standards and Recommendations:OSHA PEL: TWA 10 mg/m3
ACGIH TLV: TWA 10 mg/m3; Not Classifiable as a Human Carcinogen
DFG MAK: 1 mg/m3
Analytical Methods:For occupational chemical analysis use NIOSH: 2,4-D and 2,4,5-T, 5001.
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