CAS No.:83905-01-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	21mg/kg/3D-I (21mg/kg)	LIVER: "JAUNDICE, CHOLESTATIC" KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	American Journal of Medicine. Vol. 102, Pg. 217, 1997.
man	TDLo	oral	32mg/kg/9D-I (32mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI KIDNEY, URETER, AND BLADDER: HEMATURIA	Annals of Internal Medicine. Vol. 119, Pg. 636, 1993.
mouse	LD50	oral	3gm/kg (3000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 51, Pg. 53, 1996.
mouse	LDLo	intraperitoneal	400mg/kg (400mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 51, Pg. 53, 1996.
rat	LD50	oral	> 2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 51, Pg. 53, 1996.
rat	LDLo	intraperitoneal	900mg/kg (900mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 51, Pg. 53, 1996.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes of Azithromycin (CAS NO.83905-01-5): Xi
RTECS: RN6960000
The Most common side effects are gastrointestinal; diarrhea , nausea , abdominal pain and vomiting.Serious allergic reactions, nervousness, dermatologic reactions, and fatalities have been reported  extremely rare.As with all antimicrobial agents, pseudomembranous colitis can occur during and up to several weeks after azithromycin therapy. Azithromycin may interfere with the effectiveness of birth control pills; other forms of contraception may be required during the treatment period.

Standards and Recommendations：

 

Analytical Methods：