CAS No.:59333-67-4

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	oral	> 50mg/kg (50mg/kg)		Journal of Clinical Psychiatry. Vol. 46(3, Pg. Sec,
child	TDLo	oral	26mg/kg (26mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 28, Pg. 587, 1989.
dog	LD	oral	> 100mg/kg (100mg/kg)		Journal of Clinical Psychiatry. Vol. 46(3, Pg. Sec,
guinea pig	LD	oral	> 250mg/kg (250mg/kg)		Journal of Clinical Psychiatry. Vol. 46(3, Pg. Sec,
human	TDLo	oral	7770ug/kg (7.77mg/kg)	BEHAVIORAL: TREMOR CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Emergency Medicine. Vol. 10, Pg. 115, 1992.
man	TDLo	oral	3733ug/kg/24H (3.733mg/kg)	BEHAVIORAL: SLEEP BEHAVIORAL: EUPHORIA BEHAVIORAL: AGGRESSION	American Journal of Psychiatry. Vol. 143, Pg. 686, 1985.
man	TDLo	oral	12mg/kg/8W-I (12mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	American Journal of Psychiatry. Vol. 150, Pg. 1750, 1993.
man	TDLo	oral	208mg/kg/2Y-I (208mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: MUSCLE WEAKNESS LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"	Mayo Clinic Proceedings. Vol. 74, Pg. 692, 1999.
monkey	LD	oral	> 50mg/kg (50mg/kg)		Journal of Clinical Psychiatry. Vol. 46(3, Pg. Sec,
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		Toxicology and Applied Pharmacology. Vol. 32, Pg. 129, 1975.
mouse	LD50	oral	248mg/kg (248mg/kg)		Journal of Clinical Psychiatry. Vol. 46(3, Pg. Sec,
rat	LD50	oral	452mg/kg (452mg/kg)		Journal of Clinical Psychiatry. Vol. 46(3, Pg. Sec,
women	TDLo	oral	400ug/kg (0.4mg/kg)	BEHAVIORAL: EXCITEMENT	Journal of Clinical Psychiatry. Vol. 50, Pg. 339, 1989.
women	TDLo	oral	800ug/kg/2D-I (0.8mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE	Journal of Clinical Psychiatry. Vol. 52, Pg. 174, 1991.
women	TDLo	oral	2800ug/kg/1W- (2.8mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of Clinical Psychiatry. Vol. 55, Pg. 118, 1994.
women	TDLo	oral	5600ug/kg/2W- (5.6mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	British Journal of Psychiatry. Vol. 159, Pg. 737, 1991.
women	TDLo	oral	5600ug/kg/2W- (5.6mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: HEADACHE MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES	Journal of Clinical Psychiatry. Vol. 54, Pg. 432, 1993.
women	TDLo	oral	8mg/kg/4W-I (8mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: HEADACHE	Journal of Clinical Psychiatry. Vol. 54, Pg. 235, 1993.
women	TDLo	oral	8400ug/kg/3W- (8.4mg/kg)	CARDIAC: CHANGE IN RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Emergency Medicine. Vol. 20, Pg. 194, 1991.
women	TDLo	oral	13600ug/kg (13.6mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	Journal of Toxicology, Clinical Toxicology. Vol. 27, Pg. 389, 1989.
women	TDLo	oral	17mg/kg/2W-I (17mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN	Journal of Clinical Psychiatry. Vol. 55, Pg. 118, 1994.
women	TDLo	oral	28mg/kg/7W-I (28mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Medical Journal of Australia. Vol. 156, Pg. 364, 1992.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements: 22-38-41
22:Harmful if swallowed
38:Irritating to the skin
41:Risk of serious damage to eyes  
Safety Statements: 26-36/37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection

Standards and Recommendations：

 

Analytical Methods：