CAS No.:955-48-6
Name: Metalol hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intraperitoneal | 485mg/kg (485mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA |
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965. |
mouse | LD50 | intraperitoneal | 785mg/kg (785mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA |
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965. |
mouse | LD50 | oral | > 6gm/kg (6000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965. |
rabbit | LD50 | oral | 1250mg/kg (1250mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA |
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965. |
rat | LD50 | intraperitoneal | 850mg/kg (850mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA |
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965. |
rat | LD50 | oral | > 6gm/kg (6000mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965. |
Consensus Reports:
SAFETY PROFILE:
Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of NOx, SOx, and HCl. See also SULFONATES.
Standards and Recommendations:
Analytical Methods:
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