CAS No.:66-79-5
Name: Oxacillin
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 2550mg/kg/17D (2550mg/kg) | blood: agranulocytosis | Journal of Pediatrics. Vol. 90, Pg. 668, 1977. |
| guinea pig | LD50 | unreported | 120mg/kg (120mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977. | |
| infant | TDLo | intravenous | 3800mg/kg/19D (3800mg/kg) | blood: agranulocytosis | Journal of Pediatrics. Vol. 89, Pg. 769, 1976. |
| man | TDLo | intravenous | 3800mg/kg/19D (3800mg/kg) | blood: agranulocytosis | Journal of Pediatrics. Vol. 89, Pg. 769, 1976. |
| mouse | LD50 | intravenous | 1490mg/kg (1490mg/kg) | Pharmaceutical Chemistry Journal Vol. 1, Pg. 245, 1967. | |
| mouse | LD50 | oral | 6500mg/kg (6500mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 95, 1982. | |
| mouse | LD50 | unreported | 28gm/kg (28000mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977. | |
| rat | LD50 | unreported | 10gm/kg (10000mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977. | |
| women | TDLo | intravenous | 40mg/kg/7H-I (40mg/kg) | skin and appendages (skin): "dermatitis, other: after systemic exposure" | Annals of Pharmacotherpy. Vol. 33, Pg. 1060, 1999. |
| women | TDLo | intravenous | 5560mg/kg/20D (5560mg/kg) | blood: agranulocytosis | Southern Medical Journal. Vol. 70, Pg. 1245, 1977. |
| women | TDLo | oral | 200mg/kg/10D- (200mg/kg) | gastrointestinal: other changes | Southern Medical Journal. Vol. 77, Pg. 532, 1984. |
Consensus Reports：
SAFETY PROFILE：
Poison by an unspecified route. Moderately toxic by ingestion and intravenous routes. Human systemic effects: angranulocytosis. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also PENICILLIN; PENICILLIN compounded with CHOLINE CHLORIDE; PENICILLIN G BENETHAMINE; PENICILLIN G EPHEDRINE SALT; PENICILLIN G PROCAINE.
Standards and Recommendations：
Analytical Methods：
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