CAS No.:10028-15-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LC50	inhalation	34500ppb/3H (34.5ppm)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Industrial Medicine and Surgery. Vol. 25, Pg. 301, 1956.
guinea pig	LC50	inhalation	24800ppb/3H (24.8ppm)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Industrial Medicine and Surgery. Vol. 26, Pg. 63, 1957.
hamster	LC50	inhalation	10500ppb/4H (10.5ppm)		AMA Archives of Industrial Health. Vol. 15, Pg. 181, 1957.
human	LCLo	inhalation	50ppm/30M (50ppm)	BEHAVIORAL: HEADACHE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 446, 1969.
human	TCLo	inhalation	200ppb/4H/4D- (0.2ppm)	CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Journal of Respiratory and Critical Care Medicine. Vol. 161, Pg. 1855, 2000.
human	TCLo	inhalation	600ppb/2H (0.6ppm)	LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Review of Respiratory Disease. Vol. 118, Pg. 287, 1978.
human	TCLo	inhalation	1ppm (1ppm)	LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Environmental Health. Vol. 10, Pg. 295, 1965.
human	TCLo	inhalation	100ppm/1M (100ppm)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	News Edition, American Chemical Society. Vol. 19, Pg. 686, 1941.
man	TCLo	inhalation	80ppb/6.6H (0.08ppm)	LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives of Environmental Health. Vol. 46, Pg. 145, 1991.
man	TCLo	inhalation	1860ppb/75M (1.86ppm)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: COUGH	Archives of Environmental Health. Vol. 10, Pg. 517, 1965.
mouse	LC50	inhalation	12600ppb/3H (12.6ppm)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE	Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 16, Pg. 22, 1957.
rabbit	LC50	inhalation	36ppm/3H (36ppm)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Industrial Medicine and Surgery. Vol. 25, Pg. 301, 1956.
rat	LC50	inhalation	4800ppb/4H (4.8ppm)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE	AMA Archives of Industrial Health. Vol. 15, Pg. 181, 1957.
women	TCLo	inhalation	350ppb/75M (0.35ppm)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Inhalation Toxicology. Vol. 12, Pg. 151, 2000.

Consensus Reports：

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

SAFETY PROFILE：

A human poison by inhalation. Human systemic effects by inhalation: visual field changes, lachrymation, headache, decreased pulse rate with fall in blood pressure, dermatitis, cough, dyspnea, respiratory stimulation and other pulmonary changes. Experimental teratogenic and reproductive effects. Human mutation data reported. A skin, eye, upper respiratory system, and mucous membrane irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Can be a safe water disinfectant in low concentration. Concentration of 0.015 ppm of ozone in air produces a barely detectable odor. Concentrations of 1 ppm produce a disagreeable sulfur like odor and may cause headache and irritation of eyes and the upper respiratory tract; symptoms disappear after leaving the exposure.
A powerful oxidizing agent. Dangerous chemical reaction with acetylene, alkenes, alkylmetals (e.g., dimethylzinc, diethylzinc), antimony, aromatic compounds (e.g., benzene, aniline), benzene + oxygen + rubber, bromine, charcoal + potassium iodide, citronellic acid, combustible gases (e.g., carbon monoxide, ethylene, nitrogen oxide, ammonia, phosphine), (diallyl methyl carbinol + acetic acid), trans-2,3-dichloro-2-butene, dicyanogen, dienes + oxygen, diethyl ether, 1,1-difluoroethylene, N₂O₅, ethylene + formyl fluoride, fluoroethylene, liquid hydrogen, hydrogen + oxygen difluoride, hydrogen bromide, hydrogen iodide, 4-hydroxy-4-methyl-1,6-heptadiene, 2,3-hydroxy-2,2,4-trimethyl-3-pentenoic acid lactone, isopropylidene compounds, nitrogen, NO2, NO, nitrogen trichloride, nitrogen triiodide, nitroglycerin, organic liquids, organic matter, oxygen + rubber powder, oxygen fluorides (e.g., dioxygen difluoride, dioxygen trifluoride), silica gel, stibine, tetrafluorohydrazine, tetramethylammonium hydroxide, trifluoroethylene, unsaturated acetals. A severe explosion hazard in liquid form when shocked, exposed to heat or flame, or in concentrated form by chemical reaction with powerful reducing agents. Incompatible with rubber; dinitrogen tetraoxide.
Severe explosion hazard when shocked, exposed to heat or flame, or by chemical reaction with organic substances, especially reducing agents. Ozone is a powerful oxidizing agent. Incompatible with alkenes; aromatic compounds; benzene, rubber; bromine; dicyanogen; diethyl ether; dinitrogen tetroxide; hydrogen bromide; 4-hydroxy-4-methyl-1,6-heptadiene; nitrogen trichloride; stibine; tetrafluorohydrazine. Avoid contact with organic materials.
RIDADR: 1956
HazardClass: 2.2

Standards and Recommendations：

OSHA PEL: TWA 0.1 ppm; STEL 0.3 ppm
ACGIH TLV: TWA 0.05 ppm (heavy work), 0.08 ppm (moderate work), 0.10 (light work); all workloads < 2 hours 20 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans

Analytical Methods：