CAS No.:10028-15-6
Name: Ozone
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LC50 | inhalation | 34500ppb/3H (34.5ppm) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Industrial Medicine and Surgery. Vol. 25, Pg. 301, 1956. |
guinea pig | LC50 | inhalation | 24800ppb/3H (24.8ppm) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Industrial Medicine and Surgery. Vol. 26, Pg. 63, 1957. |
hamster | LC50 | inhalation | 10500ppb/4H (10.5ppm) | AMA Archives of Industrial Health. Vol. 15, Pg. 181, 1957. | |
human | LCLo | inhalation | 50ppm/30M (50ppm) | BEHAVIORAL: HEADACHE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 446, 1969. |
human | TCLo | inhalation | 200ppb/4H/4D- (0.2ppm) | CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
American Journal of Respiratory and Critical Care Medicine. Vol. 161, Pg. 1855, 2000. |
human | TCLo | inhalation | 600ppb/2H (0.6ppm) | LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
American Review of Respiratory Disease. Vol. 118, Pg. 287, 1978. |
human | TCLo | inhalation | 1ppm (1ppm) | LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Archives of Environmental Health. Vol. 10, Pg. 295, 1965. |
human | TCLo | inhalation | 100ppm/1M (100ppm) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
News Edition, American Chemical Society. Vol. 19, Pg. 686, 1941. |
man | TCLo | inhalation | 80ppb/6.6H (0.08ppm) | LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Archives of Environmental Health. Vol. 46, Pg. 145, 1991. |
man | TCLo | inhalation | 1860ppb/75M (1.86ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: COUGH |
Archives of Environmental Health. Vol. 10, Pg. 517, 1965. |
mouse | LC50 | inhalation | 12600ppb/3H (12.6ppm) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE |
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 16, Pg. 22, 1957. |
rabbit | LC50 | inhalation | 36ppm/3H (36ppm) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Industrial Medicine and Surgery. Vol. 25, Pg. 301, 1956. |
rat | LC50 | inhalation | 4800ppb/4H (4.8ppm) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE |
AMA Archives of Industrial Health. Vol. 15, Pg. 181, 1957. |
women | TCLo | inhalation | 350ppb/75M (0.35ppm) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Inhalation Toxicology. Vol. 12, Pg. 151, 2000. |
Consensus Reports:
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
SAFETY PROFILE:
A human poison by inhalation. Human systemic effects by inhalation: visual field changes, lachrymation, headache, decreased pulse rate with fall in blood pressure, dermatitis, cough, dyspnea, respiratory stimulation and other pulmonary changes. Experimental teratogenic and reproductive effects. Human mutation data reported. A skin, eye, upper respiratory system, and mucous membrane irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Can be a safe water disinfectant in low concentration. Concentration of 0.015 ppm of ozone in air produces a barely detectable odor. Concentrations of 1 ppm produce a disagreeable sulfur like odor and may cause headache and irritation of eyes and the upper respiratory tract; symptoms disappear after leaving the exposure.
A powerful oxidizing agent. Dangerous chemical reaction with acetylene, alkenes, alkylmetals (e.g., dimethylzinc, diethylzinc), antimony, aromatic compounds (e.g., benzene, aniline), benzene + oxygen + rubber, bromine, charcoal + potassium iodide, citronellic acid, combustible gases (e.g., carbon monoxide, ethylene, nitrogen oxide, ammonia, phosphine), (diallyl methyl carbinol + acetic acid), trans-2,3-dichloro-2-butene, dicyanogen, dienes + oxygen, diethyl ether, 1,1-difluoroethylene, N2O5, ethylene + formyl fluoride, fluoroethylene, liquid hydrogen, hydrogen + oxygen difluoride, hydrogen bromide, hydrogen iodide, 4-hydroxy-4-methyl-1,6-heptadiene, 2,3-hydroxy-2,2,4-trimethyl-3-pentenoic acid lactone, isopropylidene compounds, nitrogen, NO2, NO, nitrogen trichloride, nitrogen triiodide, nitroglycerin, organic liquids, organic matter, oxygen + rubber powder, oxygen fluorides (e.g., dioxygen difluoride, dioxygen trifluoride), silica gel, stibine, tetrafluorohydrazine, tetramethylammonium hydroxide, trifluoroethylene, unsaturated acetals. A severe explosion hazard in liquid form when shocked, exposed to heat or flame, or in concentrated form by chemical reaction with powerful reducing agents. Incompatible with rubber; dinitrogen tetraoxide.
Severe explosion hazard when shocked, exposed to heat or flame, or by chemical reaction with organic substances, especially reducing agents. Ozone is a powerful oxidizing agent. Incompatible with alkenes; aromatic compounds; benzene, rubber; bromine; dicyanogen; diethyl ether; dinitrogen tetroxide; hydrogen bromide; 4-hydroxy-4-methyl-1,6-heptadiene; nitrogen trichloride; stibine; tetrafluorohydrazine. Avoid contact with organic materials.
RIDADR: 1956
HazardClass: 2.2
Standards and Recommendations:
OSHA PEL: TWA 0.1 ppm; STEL 0.3 ppm
ACGIH TLV: TWA 0.05 ppm (heavy work), 0.08 ppm (moderate work), 0.10 (light work); all workloads < 2 hours 20 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
Analytical Methods:
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