CAS No.:

TOXICITY DATA with REFERENCE：

1.		mma-sat 300 µg/plate		ENMUDM    Environmental Mutagenesis. 7 (1985),471.
2.		mmo-esc 10 g/L		MUREAV    Mutation Research. 130 (1984),97.
3.		dni-hmn:fbr 10 mg/L		LIFSAK    Life Sciences. 17 (1975),767.
4.		sce-hmn-ihl 10 cigarettes/D		HEREAY    Hereditas. 88 (1978),147.
5.		mnt-mus-ipr 320 mg/kg		IJEBA6    Indian Journal of Experimental Biology. 23 (1985),145.
6.		ihl-rat TCLo:360 g/kg/2Y-I:NEO		JJIND8    JNCI, Journal of the National Cancer Institute. 64 (1980),383.
7.		scu-rat TDLo:160 mg/kg/64W-I:ETA		ARZNAD    Arzneimittel-Forschung. Drug Research. 18 (1968),814.
8.		skn-mus TDLo:374 g/kg/2Y-I:CAR		TXCYAC    Toxicology. 23 (1982),177.
9.		ipr-ham TDLo:150 mg/kg (10-14D preg):NEO,TER		JCROD7    Journal of Cancer Research and Clinical Oncology. 94 (1979),249.
10.		skn-mus TD:499 g/kg/2Y-I:CAR		TXCYAC    Toxicology. 23 (1982),177.

Consensus Reports：IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 359.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 38 ,1986,p. 309.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 38 ,1986,p. 309.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
SAFETY PROFILE：
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. An experimental teratogen. Human mutation data reported. See also NICOTINE, SMOKELESS TOBACCO, and TOBACCO; TOBACCO LEAF ABSOLUTE; TOBACCO LEAF, AQUEOUS EXTRACT; TOBACCO LEAF, NICOTIANA GLAUCA; TOBACCO PLANT.