CAS No.:32986-56-4

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	intravenous	37714ug/kg (37.714mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	American Journal of Kidney Diseases. Vol. 23, Pg. 118, 1994.
mouse	LD50	intramuscular	440mg/kg (440mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse	LD50	intraperitoneal	445mg/kg (445mg/kg)		Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
mouse	LD50	intravenous	72500ug/kg (72.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Antibiotiki. Vol. 29, Pg. 361, 1984.
mouse	LD50	oral	> 11500mg/kg (11500mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse	LD50	subcutaneous	367mg/kg (367mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
pig	LD50	subcutaneous	676mg/kg (676mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
rat	LD50	intramuscular	913mg/kg (913mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.
rat	LD50	intraperitoneal	1030mg/kg (1030mg/kg)		Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat	LD50	intravenous	104mg/kg (104mg/kg)		Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat	LD50	oral	> 7500mg/kg (7500mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
rat	LD50	subcutaneous	969mg/kg (969mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	Toxicology and Applied Pharmacology. Vol. 22, Pg. 332, 1972.

Consensus Reports：

EPA Genetic Toxicology Program.

SAFETY PROFILE：

Safty information about Tobramycin (CAS NO.32986-56-4) is:
Poison by intravenous and subcutaneous routes. Moderately toxic by intramuscular and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Xi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: WK2100000
F: 3-10

Standards and Recommendations：

 

Analytical Methods：