CAS No.:87679-37-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	2gm/kg (2000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse	LD50	intraperitoneal	1285mg/kg (1285mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse	LD50	intravenous	3gm/kg (3000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse	LD50	oral	3990mg/kg (3990mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat	LD50	intraperitoneal	1420mg/kg (1420mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat	LD50	intravenous	> 2gm/kg (2000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.

Consensus Reports：

 Trandolapril (CAS NO.87679-37-6) acts by competitive inhibition of Angiotensin Converting Enzyme (ACE), a key enzyme in the renin-angiotensin system (RAS pathway) ,it plays a very important role in regulating blood pressure.

SAFETY PROFILE：

RTECS: NL6015178 
Some side effects are reported for Trandolapril (CAS NO.87679-37-6) include nausea, vomiting, or diarrhea; headache; dry cough; dizziness or lightheadedness when sitting up or standing; hypotension or fatigue.

Standards and Recommendations：

 

Analytical Methods：