CAS No.:87-99-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intramuscular	10200mg/kg (10200mg/kg)		Drugs in Japan Vol. -, Pg. 297, 1990.
mouse	LD50	intravenous	8500mg/kg (8500mg/kg)		Drugs in Japan Vol. -, Pg. 352, 1995.
mouse	LD50	oral	12500mg/kg (12500mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH LIVER: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(2), Pg. 25, 1971.
mouse	LD50	subcutaneous	18300mg/kg (18300mg/kg)		Drugs in Japan Vol. -, Pg. 297, 1990.
mouse	LDLo	intraperitoneal	22100mg/kg (22100mg/kg)		Russian Pharmacology and Toxicology Vol. 34, Pg. 124, 1971.
rabbit	LD50	intravenous	4gm/kg (4000mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 31, Pg. 726, 1972.
rabbit	LD50	oral	25gm/kg (25000mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH LIVER: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(2), Pg. 25, 1971.
rat	LD50	intramuscular	15gm/kg (15000mg/kg)		Drugs in Japan Vol. -, Pg. 297, 1990.
rat	LD50	intravenous	10800mg/kg (10800mg/kg)		Drugs in Japan Vol. -, Pg. 297, 1990.
rat	LD50	oral	16500mg/kg (16500mg/kg)		Drugs in Japan Vol. -, Pg. 297, 1990.
rat	LD50	subcutaneous	> 25gm/kg (25000mg/kg)		Drugs in Japan Vol. -, Pg. 297, 1990.

Consensus Reports：

 

SAFETY PROFILE：

  Xylitol (CAS NO.87-99-0) was consumed as much as 400 grams daily for long periods with no toxicity . Like most sugar alcohols, it has a laxative effect because sugar alcohols are not fully broken down during digestion.
   Dogs that have ingested foods containing high levels of xylitol(87-99-0) (greater than 100 milligram of xylitol(87-99-0) consumed per kilogram of bodyweight) have presented with low blood sugar (hypoglycaemia) which can be life-threatening. Low blood sugar can result in a loss of coordination, depression, collapse and seizures in as soon as 30 minutes. Intake of very high doses of xylitol(87-99-0) (greater than 500 - 1000 mg/kg bwt) has also been implicated in liver failure in dogs, which can be fatal. These are points of controversy, however, as earlier World Health Organization studies using much higher doses on dogs for long periods showed no ill effect.  
Hazard Codes: Xi
Risk Statements: 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26 
S24/25: Avoid contact with skin and eyes. 
S36: Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 2
RTECS: ZF0800000

Standards and Recommendations：

 

Analytical Methods：