Amphadase (hyaluronidase) is a genetically designed protein.
Amphadase is used as an aid in helping your body absorb other injected medications.
Amphadase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.
Amphadase may also be used for other purposes not listed in this medication guide.
Important information
Your doctor may perform a skin test before using Amphadase to see if you are allergic to hyaluronidase.
Before receiving Amphadase, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine).
Before receiving Amphadase?
You should not receive Amphadase if you are allergic to hyaluronidase.
Your doctor may perform a skin test before using Amphadase to see if you are allergic to this medicine.
FDA pregnancy category C. It is not known whether Amphadase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether hyaluronidase passes into breast milk or if it could harm a nursing baby. Do not use Amphadase without telling your doctor if you are breast-feeding a baby.
See also: Pregnancy and breastfeeding warnings (in more detail)
How should I use Amphadase?
Amphadase is injected under the skin. A healthcare provider will give you this injection.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Amphadase injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid?
Follow your doctor"s instructions about any restrictions on food, beverages, or activity while you are using Amphadase.
Amphadase side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Amphadase: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Less serious Amphadase side effects may include pain, itching, redness, or swelling where the medication was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Amphadase?
Before receiving Amphadase, tell your doctor if you are using any of the following drugs:
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furosemide (Lasix);
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phenytoin (Dilantin);
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a sedative or anxiety medication (such as Valium, Xanax, Tranxene);
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aspirin or salicylates;
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cortisone or ACTH (Corticotropin);
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estrogens; or
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an antihistamine (such as a cold or allergy medicine).
This list is not complete and there may be other drugs that can interact with Amphadase. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
