Zetia reduces the amount of cholesterol or other sterols that your body absorbs from your diet.
Zetia is used to treat high cholesterol, along with a low-fat, low-cholesterol diet. It is sometimes given with other cholesterol-lowering medications. It is also used to treat high blood sitosterol and campesterol along with diet therapy.
Zetia may also be used for other purposes not listed in this medication guide.
Important information
Zetia is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Some cholesterol medications should not be taken at the same time. Do not take Zetia with cholestyramine (Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol). Wait at least 4 hours after taking any of these medicines before you take Zetia. You may also take Zetia 2 hours before taking any of these other medicines.
Zetia may be taken at the same time with fenofibrate (Antara, Lipofen, Lofibra, TriCor, Triglide), or with any of the "statin" drugs such as lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), or cerivastatin (Baycol).
In rare cases, cholesterol-lowering medication can cause a condition that results in the breakdown of skeletal muscle tissue. This condition can lead to kidney failure. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine.
What should I discuss with my healthcare provider before taking Zetia?
You should not use this medication if you are allergic to ezetimibe, or if you have liver disease.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use Zetia:
In rare cases, cholesterol-lowering medication can cause a condition that results in the breakdown of skeletal muscle tissue. This condition can lead to kidney failure. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine.
FDA pregnancy category C. It is not known whether Zetia is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ezetimibe passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
See also: Pregnancy and breastfeeding warnings (in more detail)
Older adults may be more likely to have side effects from this medicine.
How should I take Zetia?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Zetia is usually taken once a day, with or without food. Try to take Zetia at the same time each day.
Some cholesterol medications should not be taken at the same time. Do not take Zetia with cholestyramine (Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol). Wait at least 4 hours after taking any of these medicines before you take Zetia. You may also take Zetia 2 hours before taking any of these other medicines.
Zetia may be taken at the same time with fenofibrate (Antara, Lipofen, Lofibra, TriCor, Triglide), or with any of the "statin" drugs such as lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), or atorvastatin (Lipitor).
It may take up to 2 weeks of using this medicine before your cholesterol levels improve. For best results, keep using the medication as directed. Your cholesterol will need to be measured using blood tests at regular intervals. Do not miss any scheduled visits to your doctor.
Zetia is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Store Zetia at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
An overdose of Zetia is not expected to produce life-threatening symptoms.
What should I avoid?
Avoid eating foods that are high in fat or cholesterol. Zetia will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Zetia side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Zetia: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
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unusual muscle weakness, tenderness, or pain;
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nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
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chest pain;
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pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate); or/p>
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fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.
Less serious Zetia side effects may include:
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numbness or tingly feeling;
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mild stomach pain, diarrhea;
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tired feeling;
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headache;
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dizziness;
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depressed mood;
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runny or stuffy nose, cold symptoms;
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joint pain, back pain; or
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cough.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Zetia?
Before taking Zetia, tell your doctor if you are using any of the following drugs:
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cholestyramine (Prevalite, Questran);
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colestipol (Colestid);
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colesevelam (Welchol);
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gemfibrozil (Lopid);
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cyclosporine (Neoral, Sandimmune, Gengraf); or
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a blood thinner such as warfarin (Coumadin).
This list is not complete and there may be other drugs that can interact with Zetia. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
