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CAS No.:34929-08-3
Name: 1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 2gm/kg (2000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| guinea pig | LD50 | oral | 320mg/kg (320mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. | |
| hamster | LD50 | oral | > 2gm/kg (2000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: MALABSORPTION |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 673, 1974. |
| mouse | LD50 | oral | 630mg/kg (630mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| rabbit | LD50 | oral | > 2500mg/kg (2500mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
| rat | LD50 | intraperitoneal | 152mg/kg (152mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: MALABSORPTION |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 673, 1974. |
| rat | LD50 | oral | 810mg/kg (810mg/kg) | Drugs of the Future. Vol. 4, Pg. 201, 1979. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978. |
Consensus Reports：
SAFETY PROFILE：
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES.
Standards and Recommendations：
Analytical Methods：
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