CAS No.:824-11-3
Name: 1,1,1-Trishydroxymethylpropane bicyclic phosphite
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | 2500ug/kg (2.5mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
chicken | LD50 | oral | 75mg/kg (75mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
dog | LD50 | oral | 5mg/kg (5mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
guinea pig | LD50 | oral | 20mg/kg (20mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
hamster | LD50 | oral | 8mg/kg (8mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
mouse | LD50 | intraperitoneal | 1100ug/kg (1.1mg/kg) | Chemical & Engineering News. Vol. 52(1), Pg. 56, 1974. | |
mouse | LD50 | oral | 3320ug/kg (3.32mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
mouse | LD50 | skin | 4mg/kg (4mg/kg) | Science. Vol. 182, Pg. 1135, 1973. | |
mouse | LDLo | intravenous | 1mg/kg (1mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 207, 1978. |
quail | LD50 | oral | 10mg/kg (10mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
rabbit | LD50 | oral | 50mg/kg (50mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
rat | LCLo | inhalation | 10ppm/4H (10ppm) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
British Journal of Industrial Medicine. Vol. 27, Pg. 1, 1970. |
rat | LD50 | intraperitoneal | 1020ug/kg (1.02mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
rat | LD50 | oral | 8390ug/kg (8.39mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
rat | LD50 | skin | 929mg/kg (929mg/kg) | Archives of Toxicology. Vol. 35, Pg. 149, 1976. |
Consensus Reports:
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
SAFETY PROFILE:
Poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of POx.Safety information of Trimethylolpropane phosphite (CAS NO.824-11-3):
Hazard Codes T+
Risk Statements
21 Harmful in contact with skin
28 Very Toxic if swallowed
Safety Statements
28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36/37 Wear suitable protective clothing and gloves
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR UN 3464 6.1/PG 2
WGK Germany 3
RTECS TY6650000
F 10-18
HazardClass 6.1(a)
PackingGroup I
Standards and Recommendations:
Analytical Methods:
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