CAS No.:54-77-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intramuscular	28mg/kg (28mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS	Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 330, 1951.
mouse	LD50	intraperitoneal	18500ug/kg (18.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 97, Pg. 186, 1954.
mouse	LD50	intravenous	1600ug/kg (1.6mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	European Journal of Pharmacology. Vol. 11, Pg. 75, 1970.
mouse	LD50	subcutaneous	1030mg/kg (1030mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 61(2), Pg. 39S, 1965.
rabbit	LD50	intravenous	1mg/kg (1mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 330, 1951.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: TM3385000

Poison by intravenous, intraperitoneal, and intramuscular routes. When 1,1-Dimethyl-4-phenylpiperazine iodide (CAS NO.54-77-3) is heated to decomposition, it emits very toxic fumes of NO_x and I⁻.

Standards and Recommendations：

 

Analytical Methods：