CAS No.:488-41-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	900mg/kg (900mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
mouse	LD50	intravenous	2200mg/kg (2200mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977.
mouse	LD50	oral	1380mg/kg (1380mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
mouse	LD50	subcutaneous	2200mg/kg (2200mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
rabbit	LD50	oral	1080mg/kg (1080mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
rat	LD50	intraperitoneal	900mg/kg (900mg/kg)	BLOOD: NORMOCYTIC ANEMIA BLOOD: THROMBOCYTOPENIA	European Journal of Cancer. Vol. 4, Pg. 617, 1968.
rat	LD50	intravenous	1370mg/kg (1370mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977.
rat	LD50	oral	1500mg/kg (1500mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES BLOOD: NORMOCYTIC ANEMIA	Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
rat	LD50	subcutaneous	1240mg/kg (1240mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES BLOOD: NORMOCYTIC ANEMIA	Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.

Consensus Reports：

NCI Carcinogenesis Bioassay Completed; Results Positive: mouse, rat ( RRCRBU    Recent Results in Cancer Research. 52 (1975),1. ).

SAFETY PROFILE：

Safty information about 1,6-Dibromomannitol (CAS NO.488-41-5) is:
Moderately toxic by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of Br⁻. 
Hazard Codes:
T
Risk Statements:
R45:May cause cancer. 
R22:Harmful if swallowed.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use. 
S22:Do not breathe dust. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: OP2800000

Standards and Recommendations：

 

Analytical Methods：