CAS No.:665-66-7

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	37mg/kg (37mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
guinea pig	LD50	oral	360mg/kg (360mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
man	LDLo	oral	28571ug/kg (28.571mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE	American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man	LDLo	oral	286mg/kg (286mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT BEHAVIORAL: TOXIC PSYCHOSIS	American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man	TDLo	oral	13mg/kg/5D-I (13mg/kg)	BEHAVIORAL: EUPHORIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	American Journal of Psychiatry. Vol. 143, Pg. 1170, 1985.
man	TDLo	oral	24mg/kg/1D-I (24mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT	Annals of Emergency Medicine. Vol. 19, Pg. 668, 1990.
mouse	LD50	intraperitoneal	198mg/kg (198mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse	LD50	intravenous	95mg/kg (95mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse	LD50	oral	700mg/kg (700mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
mouse	LD50	subcutaneous	290mg/kg (290mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat	LD50	intraperitoneal	150mg/kg (150mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
rat	LD50	intravenous	90mg/kg (90mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat	LD50	oral	800mg/kg (800mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat	LD50	subcutaneous	500mg/kg (500mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 1269, 1971.
women	LDLo	oral	50mg/kg (50mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: PULSE RATE	American Journal of Medicine. Vol. 77, Pg. 388, 1984.

Consensus Reports：

 

SAFETY PROFILE：

Safety Information of Amantadine hydrochloride (CAS NO.665-66-7):
Hazard Codes: Xn
Risk Statements: 22-40-20/21/22
20: Harmful by inhalation 
21: Harmful in contact with skin 
22: Harmful if swallowed 
40: Limited evidence of a carcinogenic effect 
Safety Statements: 22-36/37-36
22: Do not breathe dust 
36: Wear suitable protective clothing  
37: Wear suitable gloves 

Standards and Recommendations：

 

Analytical Methods：