CAS No.:78499-27-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	191mg/kg (191mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
mouse	LD50	oral	212mg/kg (212mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
mouse	LD50	subcutaneous	387mg/kg (387mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat	LD50	intraperitoneal	391mg/kg (391mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat	LD50	oral	147mg/kg (147mg/kg)	BEHAVIORAL: ANALGESIA	Journal of Medicinal Chemistry. Vol. 25, Pg. 1065, 1982.
rat	LD50	subcutaneous	483mg/kg (483mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat	LDLo	intravenous	160mg/kg (160mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 108, Pg. 788, 1988.

Consensus Reports：

 

SAFETY PROFILE：

Poison by ingestion, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Standards and Recommendations：

 

Analytical Methods：