CAS No.:121-14-2

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	subcutaneous	25mg/kg (25mg/kg)		U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 110, 1941.
guinea pig	LD50	skin	> 1gm/kg (1000mg/kg)		National Technical Information Service. Vol. OTS0572393,
mouse	LD50	oral	790mg/kg (790mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(8), Pg. 50, 1981.
rat	LD50	oral	268mg/kg (268mg/kg)		National Technical Information Service. Vol. PB214-270,

Consensus Reports：

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-54 ,1978. ; Some Evidence: rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-54 ,1978. . Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Poison by ingestion and subcutaneous routes. Experimental reproductive effects. A skin irritant. Mutation data reported. An irritant and an allergen. Can cause anemia, methemoglobinemia, cyanosis, and liver damage. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use water spray or mist, dry chemical. Decomposes when heated to 250°C. There are instances of explosion during manufacture or storage. Mixture with nitric acid is a high explosive. Mixture with sodium carbonate can decompose with significant pressure increase at 210°C. Mixtures with other alkalies may have the same effect. Ignites on contact with sodium oxide. When heated to decomposition it emits toxic fumes of NO_x. 
Hazard Codes: T, N, F 
Risk Statements: 45-23/24/25-48/22-51/53-62-68-39/23/24/25-11 
R45:May cause cancer. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed. 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R62:Risk of impaired fertility. 
R68:Possible risk of irreversible effects. 
R39/23/24/25:Danger of very serious irreversible effects and Toxic by inhalation, in contact with skin and if swallowed. 
R11:Highly flammable.
Safety Statements: 53-45-61-36/37 
S53:Avoid exposure - obtain special instructions before use. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S36/37:Wear suitable protective clothing and gloves.
RIDADR: UN 3454 6.1/PG 2
WGK Germany: 3
RTECS: XT1575000
HazardClass: 6.1
PackingGroup: II

Standards and Recommendations：

OSHA PEL: TWA 1.5 mg/m³ (skin)
NIOSH REL: (Dinitrotoluene) Reduce to lowest level

Analytical Methods：

For occupational chemical analysis use OSHA: #44.