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Current position:Home > Products > 2,5-Dihydrothiophene Dioxide

CAS No.:77-79-2

Name: 2,5-Dihydrothiophene Dioxide

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1700mg/kg (1700mg/kg)   Pharmaceutical Chemistry Journal Vol. 12, Pg. 1568, 1978.
mouse LD50 oral 1600mg/kg (1600mg/kg) behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold gastrointestinal: change in structure or function of esophagus National Technical Information Service. Vol. OTS0534337,
rabbit LD50 skin > 5gm/kg (5000mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.
rat LD50 intraperitoneal 3200mg/kg (3200mg/kg) behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold gastrointestinal: changes in structure or function of salivary glands National Technical Information Service. Vol. OTS0534337,
rat LD50 oral 2547mg/kg (2547mg/kg) behavioral: tremor behavioral: ataxia gastrointestinal: changes in structure or function of salivary glands National Technical Information Service. Vol. OTS0546574,

Consensus Reports:

NCI Carcinogenesis Bioassay (gavage); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-102 ,1978. . Reported in EPA TSCA Inventory.


SAFETY PROFILE:

Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx.
Hazard Codes:
IrritantXi
Risk Statements:
R41:Risk of serious damage to the eyes. 
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 1
RTECS: XM9100000


Standards and Recommendations:

 


Analytical Methods:

 


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