CAS No.:77-79-2
Name: 2,5-Dihydrothiophene Dioxide
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1700mg/kg (1700mg/kg) | Pharmaceutical Chemistry Journal Vol. 12, Pg. 1568, 1978. | |
mouse | LD50 | oral | 1600mg/kg (1600mg/kg) | behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold gastrointestinal: change in structure or function of esophagus | National Technical Information Service. Vol. OTS0534337, |
rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. | |
rat | LD50 | intraperitoneal | 3200mg/kg (3200mg/kg) | behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold gastrointestinal: changes in structure or function of salivary glands | National Technical Information Service. Vol. OTS0534337, |
rat | LD50 | oral | 2547mg/kg (2547mg/kg) | behavioral: tremor behavioral: ataxia gastrointestinal: changes in structure or function of salivary glands | National Technical Information Service. Vol. OTS0546574, |
Consensus Reports:
NCI Carcinogenesis Bioassay (gavage); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-102 ,1978. . Reported in EPA TSCA Inventory.
SAFETY PROFILE:
Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx.
Hazard Codes:
Xi
Risk Statements:
R41:Risk of serious damage to the eyes.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 1
RTECS: XM9100000
Standards and Recommendations:
Analytical Methods:
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