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Current position:Home > Products > 2,6-PIPERAZINEDIONE-4,4-PROPYLENE DIOXOPIPERAZINE

CAS No.:21416-87-5

Name: 2,6-PIPERAZINEDIONE-4,4-PROPYLENE DIOXOPIPERAZINE

Details Introduction

TOXICITY DATA with REFERENCE:

1.   

dni-mus:emb 20 mg/L

    IJCNAW    International Journal of Cancer. 5 (1970),47.
2.   

msc-mus:lng 200 µg/L

    MUREAV    Mutation Research. 157 (1985),199.
3.   

orl-rat TDLo:37,500 µg/kg (6-8D preg):TER

    TJADAB    Teratology, A Journal of Abnormal Development. 11 (1975),119.
4.   

orl-rbt TDLo:105 mg/kg (female 6-8D post):REP

    TJADAB    Teratology, A Journal of Abnormal Development. 11 (1975),119.
5.   

ipr-rat TDLo:7488 mg/kg/52W-I:CAR,TER

    NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-78 ,1978.
6.   

ipr-rat TD:15 g/kg/Y-I:CAR,TER

    NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-78 ,1978.
7.   

ipr-mus TD:12 g/kg/Y-I:CAR

    NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-78 ,1978.
8.   

ipr-mus LD:1 g/kg/8W-I:ETA

    CNREA8    Cancer Research. 33 (1973),3069.
9.   

orl-hmn TDLo:81 mg/kg/3D-I:GIT,BLD

    CCROBU    Cancer Chemotherapy Reports, Part 1. 57 (1973),185.
10.   

orl-hmn TDLo
Consensus Reports:NCI Carcinogenesis Bioassay (ipr); Clear Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-78 ,1978. . EPA Genetic Toxicology Program.
SAFETY PROFILE:
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: nausea, thrombocytopenia, leukopenia. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

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