CAS No.:302-70-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	4mg/kg (4mg/kg)	gastrointestinal: other changes blood: leukopenia blood: other changes	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965.
monkey	LDLo	intravenous	8mg/kg (8mg/kg)	blood: leukopenia blood: other changes blood: other changes	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965.
mouse	LD50	intraperitoneal	125mg/kg (125mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rabbit	LD50	unreported	10mg/kg (10mg/kg)		Acta Chirurgica Scandinavica. Vol. 117, Pg. 197, 1959.
rat	LD50	intraperitoneal	79500ug/kg (79.5mg/kg)		Drugs in Japan Vol. 6, Pg. 256, 1982.
rat	LD50	intravenous	60mg/kg (60mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2A, Pg. 2684, 1981.
rat	LD50	oral	60mg/kg (60mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
rat	LD50	subcutaneous	76100ug/kg (76.1mg/kg)		Drugs in Japan Vol. 6, Pg. 256, 1982.
rat	LD50	unreported	83mg/kg (83mg/kg)		Acta Chirurgica Scandinavica. Vol. 117, Pg. 197, 1959.

Consensus Reports：

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 , 1975,p. 209.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; EPA Genetic Toxicology Program.

SAFETY PROFILE：

Suspected carcinogen with experimental tumorigenic data. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. 
RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup: II

Standards and Recommendations：

 

Analytical Methods：