CAS No.:591-78-6

TOXICITY DATA with REFERENCE：

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1.		skn-rbt 500 mg/24H MLD		85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,283.
2.		eye-rbt 100 mg open		AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
3.		eye-rbt 500 mg/24H MLD		85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,283.
4.		ihl-rat TCLo:2000 ppm/6H (1-21D preg):REP		EESADV    Ecotoxicology and Environmental Safety. 5 (1981),291.
5.		ihl-rat TCLo:1000 ppm/6H (1-21D preg):TER		EESADV    Ecotoxicology and Environmental Safety. 5 (1981),291.
6.		ihl-hmn TCLo:1000 ppm:EYE,CNS,GIT		NPIRI*    Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. 1 (1974),78.
7.		orl-rat LD50:2590 mg/kg		AMIHBC    AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
8.		ihl-rat LC50:8000 ppm/4H		NPIRI*    Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. 1 (1974),78.
9.		ipr-rat LDLo:914 mg/kg		RalRL#    Personal Communication to NIOSH from Robert L. Raleigh, M.D., Assistant Director of Health and Safety Lab., Eastman Kodak Company, Rochester, NY 01MAR74 .

guinea pig     LD50     unreported     914mg/kg (914mg/kg)       Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974, 
guinea pig     LDLo     oral     914mg/kg (914mg/kg)       Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974, 
human     TCLo     inhalation     1000ppm (1000ppm)     SENSE ORGANS AND SPECIAL SENSES: OTHER: EYEBEHAVIORAL: HEADACHEGASTROINTESTINAL: NAUSEA OR VOMITING     Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.
mouse     LD50     oral     2430mg/kg (2430mg/kg)     Toxicology Letters.    Vol. 30, Pg. 13, 1986.
rabbit     LD50     skin     4800mg/kg (4800mg/kg)       Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.
rat     LC50     inhalation     8000ppm/4H (8000ppm)       Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.
rat     LD50     oral     2590mg/kg (2590mg/kg)       AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat     LD50     unreported     914mg/kg (914mg/kg)       Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974, 
rat     LDLo     intraperitoneal     914mg/kg (914mg/kg)       Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974,

Consensus Reports：Reported in EPA TSCA Inventory.
SAFETY PROFILE：

Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation and skin contact. Experimental teratogenic and reproductive effects. Human systemic effects by inhalation: unspecified eye effects, headache, nausea or vomiting. A skin and eye irritant. Dangerous fire and explosion hazard when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO₂, dry chemical. See also KETONES.
Analytical Methods:  For occupational chemical analysis use NIOSH: Ketones I (Desorption in CS₂) 1300.
Hazard Codes:
    T: Toxic 
    F: Flammable 
Risk Statements about 2-HEXANONE(591-78-6):
    R10 Flammable.
    R11 Highly flammable.
    R62 Risk of impaired fertility.
    R67 Vapours may cause drowsiness and dizziness.
    R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about 2-HEXANONE(591-78-6):
    S7 Keep container tightly closed.
    S16 Keep away from sources of ignition.
    S45 In case of accident or if you feel unwell, seek medical advice immediately (show the
label whenever possible.)
    S36/37 Wear suitable protective clothing and gloves.

Standards and Recommendations：OSHA PEL: TWA 5 ppm
ACGIH TLV: TWA 5 ppm; STEL 10 ppm
DFG MAK: 5 ppm (21 mg/m³)
NIOSH REL: (Ketones) TWA 4 mg/m³
DOT Classification:  3; Label: Flammable Liquid
Analytical Methods：For occupational chemical analysis use NIOSH: Ketones I (Desorption in CS₂) 1300.