CAS No.:7055-03-0
Name: 2-Methyl-N-Phenylbenzamide
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
| rat | LD50 | oral | 6gm/kg (6000mg/kg) | "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 5, Pg. 144, 1976. |
Consensus Reports：
SAFETY PROFILE：
Poison by intraperitoneal route. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.
Standards and Recommendations：
Analytical Methods：
O-Benzoic acid and phosphorus trichloride for chloride generated reaction intermediates o-benzoyl chloride, with condensation of aniline system in neighboring amide. 24.4kg of aniline, 62.5kg sodium hydroxide solution (100% discount, according to the molar ratio of aniline 1.7 times), 100 kg of toluene were joined enamelled 11:50. Under the mixing temperature 71/92 o-benzoyl chloride, about half an hour increase End 53.0kg. Exothermic reaction, the temperature increase, when about around 70-80 ° C and then heated to 80-90 ° C 30min. After completion of the reaction, to insulation, to join the 90-95 ° C 200L hot water, stirring washed 20min, the formation of sodium chloride and unreacted raw material soluble in water, sewage Still separation of classes. Then water 50-80L, steam distillation, solvent recovery, toluene and trace aniline. Then cold to 30-40 ° C, stirring slowly crystallized into small particles of yellow, filtering, washing coffin-80 ° C dry, in the content of 93-98% of the o-lactamase and the yield more than 95%. The consumption of raw materials fixed : o-benzoic acid (>=80%) 1310kg / t, phosphorus trichloride (>=95%) 740kg / t, aniline (97%) 490kg / t, sodium hydroxide (100%) 1250kg / t.
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