CAS No.:51-15-0

TOXICITY DATA with REFERENCE：

1.		ivn-man TDLo:14 mg/kg:CNS,PUL		34ZIAG    Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,449.
2.		ivn-hmn TDLo:15 mg/kg:CVS		AEHLAU    Archives of Environmental Health. 15 (1967),599.
3.		ivn-rat LD50:96 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 16 (1970),40.
4.		ims-rat LD50:150 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 16 (1970),40.
5.		orl-mus LD50:4100 mg/kg		JPMSAE    Journal of Pharmaceutical Sciences. 53 (1964),1143.
6.		ipr-mus LD50:155 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 14 (1964),5.
7.		ivn-mus LD50:90 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 14 (1964),5.
8.		ims-mus LD50:100 mg/kg		DCTODJ    Drug and Chemical Toxicology. 8 (1985),431.
9.		ims-dog LD50:75 mg/kg		FAATDF    Fundamental and Applied Toxicology. 4 (2, Pt 2),(1984),S106.
10.		ivn-rbt LD50:95 mg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 132 (1961),50.

Consensus Reports：

 

SAFETY PROFILE：

Safety Information of 2-Hydroxyiminomethyl-1-methylpyridinium chloride (CAS NO.51-15-0):
Hazard Codes: Xn 
Risk Statements: 20/21/22-36/37/38-20/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin
R20/21:Harmful by inhalation and in contact with skin
Safety Statements: 36-37/39-26
S36:Wear suitable protective clothing
S37/39:Wear suitable gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 3
RTECS: UU4200000
Poison by intravenous, intramuscular, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by intravenous route: coma, blood pressure increase, bronchiolar constriction and cyanosis. Used as a cholinesterase reactivator. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.

Standards and Recommendations：

 

Analytical Methods：