CAS No.:134-80-5
Name: Amfepramone hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 160mg/kg (160mg/kg) | Therapie. Vol. 17, Pg. 373, 1962. | |
mouse | LD50 | intravenous | 50mg/kg (50mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 182, 1960. | |
mouse | LD50 | oral | 385mg/kg (385mg/kg) | Therapie. Vol. 17, Pg. 373, 1962. | |
mouse | LD50 | subcutaneous | 450mg/kg (450mg/kg) | sense organs and special senses: mydriasis (pupillary dilation): eye behavioral: excitement skin and appendages (skin): hair: other | Acta Pharmaceutica Suecica. Vol. 4, Pg. 37, 1967. |
rat | LD50 | intraperitoneal | 139mg/kg (139mg/kg) | behavioral: excitement | Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 121, 1960. |
rat | LD50 | oral | 400mg/kg (400mg/kg) | Therapie. Vol. 17, Pg. 373, 1962. |
Consensus Reports:
SAFETY PROFILE:
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl, NH3, and NOx.
Standards and Recommendations:
Analytical Methods:
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