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Current position:Home > Products > Amfepramone hydrochloride

CAS No.:134-80-5

Name: Amfepramone hydrochloride

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 160mg/kg (160mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.
mouse LD50 intravenous 50mg/kg (50mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 182, 1960.
mouse LD50 oral 385mg/kg (385mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.
mouse LD50 subcutaneous 450mg/kg (450mg/kg) sense organs and special senses: mydriasis (pupillary dilation): eye behavioral: excitement skin and appendages (skin): hair: other Acta Pharmaceutica Suecica. Vol. 4, Pg. 37, 1967.
rat LD50 intraperitoneal 139mg/kg (139mg/kg) behavioral: excitement Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 121, 1960.
rat LD50 oral 400mg/kg (400mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.

Consensus Reports:

 


SAFETY PROFILE:

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl, NH3, and NOx.


Standards and Recommendations:

 


Analytical Methods:

 


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