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CAS No.:37517-28-5

Name: Amikacin

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 6200mg/kg (6200mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
mouse LD50 intraperitoneal 750mg/kg (750mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Antimicrobial Agents and Chemotherapy. Vol. 13, Pg. 41, 1978.
mouse LD50 intravenous 280mg/kg (280mg/kg)   Journal of Antibiotics. Vol. 43, Pg. 858, 1990.
mouse LD50 oral > 6gm/kg (6000mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
mouse LD50 subcutaneous 6200mg/kg (6200mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.


Consensus Reports:

 


SAFETY PROFILE:

Safety Information of Amikacin (CAS NO.37517-28-5):
Hazard Codes: XiIrritant
Risk Statements: 36/37/38
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
Safety Statements: 26-36
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing 


Standards and Recommendations:

 


Analytical Methods:

 


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