CAS No.:12192-57-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	intravenous	1gm/kg (1000mg/kg)		Poultry Science. Vol. 52, Pg. 926, 1973.
chicken	LDLo	intramuscular	300mg/kg (300mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES SPINAL CORD: OTHER DEGENERATIVE CHANGES	Toxicology and Applied Pharmacology. Vol. 35, Pg. 223, 1976.
man	LDLo	unreported	3mg/kg (3mg/kg)		Sammlung von Vergiftungsfaellen. Vol. 10, Pg. 101A, 1939.
man	TDLo	intramuscular	3357ug/kg/4W- (3.357mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Journal of Rheumatology. Vol. 12, Pg. 619, 1985.
man	TDLo	intramuscular	5500ug/kg/10W (5.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Southern Medical Journal. Vol. 88, Pg. 644, 1995.
mouse	LD50	intraperitoneal	2gm/kg (2000mg/kg)	LIVER: OTHER CHANGES	Proceedings of the Society for Experimental Biology and Medicine. Vol. 70, Pg. 498, 1949.
mouse	LDLo	subcutaneous	1650mg/kg (1650mg/kg)		Experimental Medicine and Surgery. Vol. 3, Pg. 146, 1945.
women	TDLo	intramuscular	2600ug/kg/15D (2.6mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: OTHER CHANGES	Arthritis and Rheumatism. Vol. 27, Pg. 230, 1984.
women	TDLo	intramuscular	14402ug/kg/2Y (14.402mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: PROTEINURIS KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Taisha. Molecular Medicine Vol. 12, Pg. 1435, 1975.
women	TDLo	parenteral	2700ug/kg/4W- (2.7mg/kg)	LIVER: "JAUNDICE, CHOLESTATIC"	Journal of Rheumatology. Vol. 11, Pg. 843, 1984.

Consensus Reports：

IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 (1977),p. 39.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

SAFETY PROFILE：

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. A deadly human poison by an unspecified route. An experimental poison by intramuscular route. Moderately toxic by subcutaneous and intravenous routes. Human systemic effects: nausea or vomiting, cholestatic jaundice, and eye effects. An experimental teratogen. Other experimental reproductive effects. See also GOLD COMPOUNDS. When heated to decomposition it emits very toxic fumes of SO_x. 
Hazard Codes:
Xn
Risk Statements:
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements:
S22:Do not breathe dust. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2811
HazardClass: 6.1(b)
PackingGroup: III

Standards and Recommendations：

 

Analytical Methods：