CAS No.:61-75-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intramuscular	100mg/kg (100mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
dog	LD50	intravenous	43mg/kg (43mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
mouse	LD50	intramuscular	64mg/kg (64mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
mouse	LD50	intraperitoneal	39mg/kg (39mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965.
mouse	LD50	intravenous	14mg/kg (14mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
mouse	LD50	oral	400mg/kg (400mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 14, Pg. 536, 1959.
mouse	LD50	subcutaneous	72mg/kg (72mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 14, Pg. 536, 1959.
rabbit	LD50	intramuscular	160mg/kg (160mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
rabbit	LD50	intravenous	30mg/kg (30mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
rat	LD50	intramuscular	84mg/kg (84mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
rat	LD50	intraperitoneal	57mg/kg (57mg/kg)		Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 21, Pg. 256, 1980.
rat	LD50	intravenous	17mg/kg (17mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
women	TDLo	intravenous	81500ug/kg/15 (81.5mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	American Journal of Emergency Medicine. Vol. 13, Pg. 177, 1995.

Consensus Reports：

 

SAFETY PROFILE：

A poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. An anti-adrenergic agent and antiarrhythmic cardiac depressant. When heated to decomposition it emits very toxic fumes of SO_x, NH₃, NO_x, and Br⁻. See also SULFONATES.
Hazard Codes Xn
Risk Statements 20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
RTECS BO9450000

Standards and Recommendations：

 

Analytical Methods：