CAS No.:404-86-4

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	1600ug/kg (1.6mg/kg)		FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 60, 1970.
guinea pig	LD50	intraperitoneal	1100ug/kg (1.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT	Toxicon. Vol. 18, Pg. 215, 1980.
hamster	LD50	intraperitoneal	> 120mg/kg (120mg/kg)		Toxicon. Vol. 18, Pg. 215, 1980.
mouse	LD50	intramuscular	7800ug/kg (7.8mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Toxicon. Vol. 18, Pg. 215, 1980.
mouse	LD50	intraperitoneal	6500ug/kg (6.5mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicon. Vol. 18, Pg. 215, 1980.
mouse	LD50	intratracheal	1600ug/kg (1.6mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Toxicon. Vol. 18, Pg. 215, 1980.
mouse	LD50	intravenous	400ug/kg (0.4mg/kg)		Yakhak Hoe Chi. Journal of the Pharmaceutical Society. Vol. 25(3), Pg. 101, 1981.
mouse	LD50	oral	47200ug/kg (47.2mg/kg)		Yakhak Hoe Chi. Journal of the Pharmaceutical Society. Vol. 25(3), Pg. 101, 1981.
mouse	LD50	rectal	> 218mg/kg (218mg/kg)		Toxicon. Vol. 18, Pg. 215, 1980.
mouse	LD50	skin	> 512mg/kg (512mg/kg)		Toxicon. Vol. 18, Pg. 215, 1980.
mouse	LD50	subcutaneous	9000ug/kg (9mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT	Toxicon. Vol. 18, Pg. 215, 1980.
rabbit	LD50	intraperitoneal	> 50mg/kg (50mg/kg)		Toxicon. Vol. 18, Pg. 215, 1980.
rat	LD50	intraperitoneal	9500ug/kg (9.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Toxicon. Vol. 18, Pg. 215, 1980.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes of Capsaicin (CAS NO.404-86-4): T,T+
Risk Statements: 25-41-42/43-36/37/38 
R25: Toxic if swallowed. 
R41: Risk of serious damage to the eyes. 
R42/43: May cause sensitization by inhalation and skin contact. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-26-28-45-36/37/39 
S22: Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S28: After contact with skin, wash immediately with plenty of soap-suds. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: RA8530000
F: 10-21
HazardClass: 6.1(a)
PackingGroup: II

Standards and Recommendations：

 

Analytical Methods：