CAS No.:94-20-2

TOXICITY DATA with REFERENCE：

1.		sce-mus-orl 177 mg/kg		MUREAV    Mutation Research. 77 (1980),349.
2.		sce-ham-ipr 7100 µg/kg		MUREAV    Mutation Research. 77 (1980),349.
3.		orl-wmn TDLo:25 mg/kg/5D-I:BLD		DICPBB    Drug Intelligence and Clinical Pharmacy. 18 (1984),981.
4.		orl-wmn TDLo:300 mg/kg:CNS		CTOXAO    Clinical Toxicology. 11 (1977),13.
5.		orl-man TDLo:83 mg/kg/25D-I:GIT		AJGAAR    American Journal of Gastroenterology. 80 (1985),381.
6.		orl-rat LD50:2150 mg/kg		FATOAO    Farmakologiya i Toksikologiya (Moscow). 25 (1962),93.
7.		ipr-rat LD50:580 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
8.		ivn-rat LD50:590 mg/kg		PMDCAY    Progress in Medical Chemistry. 1 (1961),187.
9.		orl-mus LD50:1546 mg/kg		AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 153 (1965),379.
10.		ivn-mus LD50:500 mg/kg		PMDCAY    Progress in Medical Chemistry. 1 (1961),187.

Consensus Reports：

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-45 ,1978. . EPA Genetic Toxicology Program.

SAFETY PROFILE：

Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: hemolysis with or without anemia, ulceration or bleeding from large intestine, cholestatic jaundice. Human teratogenic effects by ingestion: fetal death. Human reproductive effects by ingestion and possibly other routes: stillbirth, reduced viability and abnormal characteristics of newborn at birth. An experimental teratogen. Experimental reproductive effects. Mutation data reported. An antidiabetic agent. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and SO_x.Safety information of Chlorpropamide (CAS NO.94-20-2):
Hazard Codes  Xn
Risk Statements 
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
40 Limited evidence of a carcinogenic effect
Safety Statements 
22 Do not breathe dust
36 Wear suitable protective clothing
WGK Germany  3
RTECS  YS6650000

Standards and Recommendations：

 

Analytical Methods：