CAS No.:54-05-7

TOXICITY DATA with REFERENCE：

child	LDLo	oral	37593ug/kg (37.593mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CHANGE IN RATE	Annals of Emergency Medicine. Vol. 19, Pg. 47, 1990.
human	LDLo	oral	20mg/kg (20mg/kg)	SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE BEHAVIORAL: COMA VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
man	LDLo	oral	86mg/kg (86mg/kg)	CARDIAC: CHANGE IN RATE CARDIAC: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING	New England Journal of Medicine. Vol. 318, Pg. 1, 1988.
mouse	LD50	intramuscular	71mg/kg (71mg/kg)		Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 4, Pg. 69, 1983.
mouse	LD50	intraperitoneal	66mg/kg (66mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1219, 1982.
mouse	LD50	intravenous	21600ug/kg (21.6mg/kg)		Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 4, Pg. 69, 1983.
mouse	LD50	oral	311mg/kg (311mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 753, 1973.
mouse	LD50	subcutaneous	150mg/kg (150mg/kg)		Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
rabbit	LD50	intravenous	8mg/kg (8mg/kg)		Therapie. Vol. 25, Pg. 823, 1970.
rabbit	LD50	subcutaneous	75mg/kg (75mg/kg)		Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
rabbit	LDLo	intramuscular	20mg/kg (20mg/kg)		Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 15, Pg. 630, 1980.
rat	LD50	intraperitoneal	102mg/kg (102mg/kg)	GASTROINTESTINAL: OTHER CHANGES	Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 401, 1975.
rat	LD50	intravenous	60mg/kg (60mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 38, 1966.
rat	LD50	oral	330mg/kg (330mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 271, 1983.
rat	LD50	subcutaneous	190mg/kg (190mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 38, 1966.
women	LDLo	oral	110mg/kg (110mg/kg)	CARDIAC: CHANGE IN RATE CARDIAC: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING	New England Journal of Medicine. Vol. 318, Pg. 1, 1988.
women	LDLo	oral	180mg/kg (180mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Medical Journal of Australia. Vol. 160, Pg. 231, 1994.
women	TDLo	oral	24mg/kg/12D-I (24mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Annals of Internal Medicine. Vol. 123, Pg. 76, 1995.
women	TDLo	oral	3600mg/kg/3Y (3600mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE GASTROINTESTINAL: OTHER CHANGES	Tropical and Geographical Medicine. Vol. 32, Pg. 216, 1980.

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