CAS No.:458-88-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	3mg/kg (3mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936.
dog	LDLo	intravenous	25mg/kg (25mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 588, 1948.
frog	LDLo	unreported	375mg/kg (375mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 595, 1948.
guinea pig	LDLo	subcutaneous	50mg/kg (50mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 593, 1948.
mouse	LD50	intravenous	19mg/kg (19mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963.
mouse	LD50	oral	100mg/kg (100mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963.
mouse	LD50	subcutaneous	80mg/kg (80mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963.
rabbit	LDLo	intravenous	15mg/kg (15mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 588, 1948.
rabbit	LDLo	subcutaneous	80mg/kg (80mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Medical Sciences, Part 4: Pharmacology. Vol. 7, Pg. 128, 1933.

Consensus Reports：

 

SAFETY PROFILE：

Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. When heated to decomposition Cicutine (CAS NO.458-88-8) emits toxic fumes of NO_x.

Standards and Recommendations：

 

Analytical Methods：