CAS No.:21368-68-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intraperitoneal	400mg/kg (400mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
child	LDLo	unreported	100mg/kg (100mg/kg)		Yakkyoku. Pharmacy. Vol. 31, Pg. 1499, 1980.
child	TDLo	oral	51mg/kg (51mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	American Journal of Emergency Medicine. Vol. 7, Pg. 41, 1989.
dog	LDLo	oral	800mg/kg (800mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	subcutaneous	240mg/kg (240mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
infant	LDLo	oral	70mg/kg (70mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	American Journal of Pathology. Vol. 30, Pg. 857, 1954.
man	LDLo	unreported	29mg/kg (29mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LCLo	inhalation	400mg/m3/3H (400mg/m3)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 22(11), Pg. 83, 1957.
mouse	LD50	intraperitoneal	3gm/kg (3000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	American Journal of Pathology. Vol. 30, Pg. 857, 1954.
mouse	LD50	oral	1310mg/kg (1310mg/kg)		Shika Gakuho. Journal of Dentistry. Vol. 75, Pg. 934, 1975.
mouse	LDLo	subcutaneous	200mg/kg (200mg/kg)	BEHAVIORAL: EXCITEMENT	"Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933.
rabbit	LDLo	oral	2gm/kg (2000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: REGIDITY	American Journal of Pathology. Vol. 30, Pg. 857, 1954.
rat	LD50	subcutaneous	70mg/kg (70mg/kg)		"Ueber die Pharmakologische Wirkung eines dem Pentamethylentetrazol Vol. -, Pg. -, 1934.
rat	LDLo	intraperitoneal	900mg/kg (900mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 275, 1939.

RTECS:  EX1225000

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes:  F,Xn  
Risk Statements:  11-22-36/37/38-36-20/21/22 (R11:Highly flammable. R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin. R36:Irritating to eyes. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.)
Safety Statements:  16-26-36 (S16:Keep away from sources of ignition. S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36:Wear suitable protective clothing.)
RIDADR:  UN 2717 4.1/PG 3
WGK Germany:  1
 

Standards and Recommendations：

 

Analytical Methods：