CAS No.:42609-52-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	skin	> 3500mg/kg (3500mg/kg)		Japan Pesticide Information. Vol. (40), Pg. 32, 1982.
mouse	LDLo	intraperitoneal	> 3500mg/kg (3500mg/kg)		Japan Pesticide Information. Vol. (36), Pg. 40, 1979.
mouse	LDLo	oral	> 6500mg/kg (6500mg/kg)		Japan Pesticide Information. Vol. (36), Pg. 40, 1979.
mouse	LDLo	subcutaneous	> 3500mg/kg (3500mg/kg)		Japan Pesticide Information. Vol. (36), Pg. 40, 1979.
rat	LD50	skin	> 3500mg/kg (3500mg/kg)		Japan Pesticide Information. Vol. (40), Pg. 32, 1982.
rat	LDLo	intraperitoneal	> 3500mg/kg (3500mg/kg)		Japan Pesticide Information. Vol. (36), Pg. 40, 1979.
rat	LDLo	oral	> 4gm/kg (4000mg/kg)		Japan Pesticide Information. Vol. (36), Pg. 40, 1979.
rat	LDLo	subcutaneous	> 3500mg/kg (3500mg/kg)		Japan Pesticide Information. Vol. (36), Pg. 40, 1979.

Consensus Reports：

 

SAFETY PROFILE：

Mildly toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x.

Standards and Recommendations：

 

Analytical Methods：

P-urea method
P-urea preparation of sodium cyanate with the reaction of p-toluidine hydrochloride solution to control the reaction temperature is 30°C, a little too much sodium cyanate, urea obtained for toluene. Urea, sodium cyanate can be made with calcined sodium carbonate.
Preparation of chloro-isopropylbenzene 2 - phenyl-propene in acetonitrile solvent with hydrogen chloride addition, the introduction of chlorine atom side chain to produce chlorinated cumene.
Herbicide-long synthesis of p-cumene role of urea and chloride, synthetic herbicide lung. Join toluene urea 0.15mol, chloride, cumene 0.1mol, α-methyl styrene 48g and acetonitrile 160g, at 40 °C stirring reaction 6h, put it aside at room temperature, separation of crystals 32g, yield 80%.
α, α-dimethyl benzyl isocyanate France
Law is the α, α-2-methyl chloride in non-aqueous organic solvents and metal chloride catalysts in the presence of sodium cyanate reacted with α, α-dimethyl benzyl isocyanate, filtered to remove sodium chloride by-product , and then with the addition of p-toluidine obtained a good yield of herbicide-lung. Such as: in the reactor by adding ethyl acetate 50mL, 90% sodium cyanate 6.5g (90mmol), zinc chloride (0.5mol), pyridine (1mmol), stirring heated to 50°C, and then join the α, α-2 Methyl chloride 7.73g (50mmol) at 50 °C reaction 1h. Obtained α, α-dimethyl benzyl isocyanate. α, α-dimethyl benzyl isocyanate, and p-toluidine in toluene or chlorobenzene in addition, the almost quantitative yield of herbicide-lung.