CAS No.:1972-08-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	525mg/kg (525mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology and Applied Pharmacology. Vol. 25, Pg. 363, 1973.
monkey	LD	oral	> 3150mg/kg (3150mg/kg)		Toxicology and Applied Pharmacology. Vol. 25, Pg. 363, 1973.
monkey	LD50	intravenous	125mg/kg (125mg/kg)		Medical Journal of Australia. Vol. 145, Pg. 82, 1986.
mouse	LD50	intracrebral	> 12580ug/kg (12.58mg/kg)		Research Communiations in Alcohol and Substances of Abuse. Vol. 17, Pg. 151, 1996.
mouse	LD50	intraperitoneal	168mg/kg (168mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 196, Pg. 133, 1972.
mouse	LD50	intravenous	42mg/kg (42mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Annals of the New York Academy of Sciences. Vol. 191, Pg. 74, 1971.
mouse	LD50	oral	482mg/kg (482mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Proceedings of the Society for Experimental Biology and Medicine. Vol. 136, Pg. 260, 1971.
mouse	LD50	subcutaneous	> 11gm/kg (11000mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 154, 1946.
rat	LD50	intraperitoneal	373mg/kg (373mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Proceedings of the Society for Experimental Biology and Medicine. Vol. 136, Pg. 260, 1971.
rat	LD50	intravenous	29mg/kg (29mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: EXCITEMENT	Annals of the New York Academy of Sciences. Vol. 191, Pg. 74, 1971.
rat	LD50	oral	666mg/kg (666mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Proceedings of the Society for Experimental Biology and Medicine. Vol. 136, Pg. 260, 1971.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: F
Risk Statements: 11 
R11:Highly flammable.
Safety Statements: 16-7 
S7:Keep container tightly closed. 
S16:Keep away from sources of ignition.

Standards and Recommendations：

 

Analytical Methods：