CAS No.:70052-12-9
Name: Eflornithine
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | intravenous | 9084mg/kg/2W- (9084mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: THROMBOCYTOPENIA |
Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 627, 1987. |
| man | TDLo | oral | 800mg/kg/4D-I (800mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: THROMBOCYTOPENIA |
Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 627, 1987. |
| women | LDLo | intravenous | 67mg/kg/40M-C (67mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Annals of Internal Medicine. Vol. 105, Pg. 141, 1986. |
Consensus Reports：
SAFETY PROFILE：
Human systemic effects by intravenous route: cardiomyopathy, pulse rate decrease, fall in blood pressure. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of F− and NOx.
Standards and Recommendations：
Analytical Methods：
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