CAS No.:58-54-8

TOXICITY DATA with REFERENCE：

1.		orl-wmn TDLo:4 mg/kg:EAR		AIMDAP    Archives of Internal Medicine. 117 (1966),715.
2.		orl-man TDLo:3 mg/kg:EAR,KID		AIMDAP    Archives of Internal Medicine. 117 (1966),715.
3.		ivn-wmn TDLo:3 mg/kg:EAR		AIMDAP    Archives of Internal Medicine. 117 (1966),715.
4.		orl-rat LD50:1 g/kg		YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775.
5.		ipr-rat LD50:43 mg/kg		OYYAA2    Oyo Yakuri. Pharmacometrics. 2 (1968),411.
6.		orl-mus LD50:627 mg/kg		MEIEDD    Merck Index. 10 (1983),539.
7.		ivn-mus LD50:176 mg/kg		MEIEDD    Merck Index. 10 (1983),539.

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion and intravenous routes: urine volume increase, impaired hearing, and tinnitus (ringing in the ears). A diuretic. When heated to decomposition it emits toxic fumes of Cl⁻.Safety information of Ethacrynic acid (CAS NO.58-54-8):
Hazard Codes  Xn
Risk Statements 
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements 
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
WGK Germany  3
RTECS  AG6600000

Standards and Recommendations：

 

Analytical Methods：