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CAS No.:30544-47-9

Name: Etofenamate

Details Introduction

TOXICITY DATA with REFERENCE:

1.    

orl-rat LD50:292 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
2.    

ipr-rat LD50:373 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
3.    

scu-rat LD50:568 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
4.    

ivn-rat LD50:139 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
5.    

orl-mus LD50:743 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
6.    

scu-mus LD50:1897 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
7.    

ivn-mus LD50:75 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
8.    

scu-rbt LD50:1532 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.

Consensus Reports:

 


SAFETY PROFILE:

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. Experimental teratogenic and reproductive effects. Used as an anti-inflammatory agent. When heated to decomposition it emits very toxic fumes of F and NOx. See also FLUORIDES.


Standards and Recommendations:

 


Analytical Methods:

Uv max (methanol): 286 (E1%1cm 423). nD25 1.564.


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