CAS No.:50847-11-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	460mg/kg (460mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	intravenous	146mg/kg (146mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	oral	1860mg/kg (1860mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	subcutaneous	3100mg/kg (3100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	intraperitoneal	419mg/kg (419mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	intravenous	42500ug/kg (42.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE KIDNEY, URETER, AND BLADDER: HEMATURIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	oral	1340mg/kg (1340mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	subcutaneous	1300mg/kg (1300mg/kg)	KIDNEY, URETER, AND BLADDER: HEMATURIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.

Consensus Reports：

 

SAFETY PROFILE：

Safety Information about Ibudilast (CAS NO.50847-11-5):
Hazard Codes: Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: UR0711200

Standards and Recommendations：

 

Analytical Methods：