CAS No.:15687-27-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	469mg/kg (469mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Annals of Emergency Medicine. Vol. 15, Pg. 1308, 1986.
child	TDLo	oral	480mg/kg/17D- (480mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	Journal of Pediatrics. Vol. 90, Pg. 657, 1977.
child	TDLo	oral	500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Annals of Pharmacotherpy. Vol. 31, Pg. 432, 1997.
guinea pig	LD50	oral	495mg/kg (495mg/kg)		Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
hamster	LD50	oral	1690mg/kg (1690mg/kg)		Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
mammal (species unspecified)	LD50	oral	1gm/kg (1000mg/kg)		Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 545, 1985.
man	LDLo	oral	171mg/kg (171mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	British Medical Journal. Vol. 281, Pg. 1458, 1980.
man	TDLo	oral	120mg/kg/W-I (120mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	New York State Journal of Medicine. Vol. 78, Pg. 1239, 1978.
man	TDLo	oral	180mg/kg/3W-I (180mg/kg)	LIVER: "JAUNDICE, CHOLESTATIC"	American Journal of Gastroenterology. Vol. 91, Pg. 1626, 1996.
man	TDLo	oral	429mg/kg (429mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 315, 1994.
man	TDLo	oral	800mg/kg (800mg/kg)	BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Postgraduate Medical Journal. Vol. 69, Pg. 575, 1993.
man	TDLo	oral	1028mg/kg (1028mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	American Journal of Emergency Medicine. Vol. 13, Pg. 375, 1995.
mouse	LD50	intraperitoneal	320mg/kg (320mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Toxicology and Applied Pharmacology. Vol. 15, Pg. 310, 1969. Link to PubMed
mouse	LD50	oral	740mg/kg (740mg/kg)	BEHAVIORAL: ANALGESIA	Pharmaceutical Chemistry Journal Vol. 14, Pg. 119, 1980.
mouse	LD50	rectal	620mg/kg (620mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
mouse	LD50	subcutaneous	395mg/kg (395mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
rabbit	LD50	oral	1400mg/kg (1400mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1032, 1990.
rabbit	LD50	rectal	830mg/kg (830mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1032, 1990.
rat	LD50	intraperitoneal	626mg/kg (626mg/kg)	BEHAVIORAL: ANALGESIA	Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1006, 1977.
rat	LD50	oral	636mg/kg (636mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 280, 1984.
rat	LD50	rectal	530mg/kg (530mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
rat	LD50	subcutaneous	740mg/kg (740mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.
women	TDLo	oral	8mg/kg (8mg/kg)	BEHAVIORAL: HEADACHE	JAMA, Journal of the American Medical Association. Vol. 239, Pg. 1062, 1978.
women	TDLo	oral	132mg/kg/6D-I (132mg/kg)	BLOOD: THROMBOCYTOPENIA	British Journal of Clinical Practice. Vol. 48, Pg. 51, 1994.
women	TDLo	unreported	96mg/kg/3D-I (96mg/kg)	SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE	JAMA, Journal of the American Medical Association. Vol. 248, Pg

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,N
Risk Statements: 22-63-51/53
R22: Harmful if swallowed 
R63: Possible risk of harm to the unborn child 
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 61-36/37
S61: Avoid release to the environment. Refer to special instructions safety data sheet 
S36/37:  Wear suitable protective clothing and gloves
RIDADR: 2811
WGK Germany: 3
RTECS: MU6640000
HazardClass: 6.1(b)
PackingGroup: III

Standards and Recommendations：

 

Analytical Methods：