CAS No.:58186-27-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	> 1gm/kg (1000mg/kg)		Chemical and Pharmaceutical Bulletin. Vol. 39, Pg. 367, 1991.
mouse	LD50	intraperitoneal	757mg/kg (757mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.
rat	LD50	intraperitoneal	830mg/kg (830mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.
rat	LD50	oral	10gm/kg (10000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.

Consensus Reports：

 

SAFETY PROFILE：

Although studies in animals have shown no harmful effects, this product should not be taken during the first three months of pregnancy and during nursing, only when absolutely necessary and always under a doctor's supervision.
Hazard Codes: Xi
RTECS: GU5290000

Standards and Recommendations：

 

Analytical Methods：