CAS No.:7640-37-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intraperitoneal	325mg/kg (325mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Klinische Wochenscrift. Vol. 30, Pg. 959, 1952.
child	TDLo	oral	125mg/kg (125mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Annals of Emergency Medicine. Vol. 17, Pg. 73, 1988.
child	TDLo	oral	195mg/kg (195mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: HEADACHE	Japanese Journal of Toxicology. Vol. 12, Pg. 225, 1999.
child	TDLo	oral	3600mg/kg/43W (3600mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR	Canadian Medical Association Journal. Vol. 148, Pg. 49, 1993.
dog	LD50	oral	50mg/kg (50mg/kg)		American Review of Tuberculosis. Vol. 65, Pg. 392, 1952.
guinea pig	LD50	intramuscular	255mg/kg (255mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
guinea pig	LD50	intraperitoneal	195mg/kg (195mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Klinische Wochenscrift. Vol. 30, Pg. 959, 1952.
guinea pig	LD50	intravenous	220mg/kg (220mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Archiv fuer Toxikologie. Vol. 22, Pg. 80, 1966.
guinea pig	LD50	oral	255mg/kg (255mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
guinea pig	LD50	subcutaneous	195mg/kg (195mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
human	LDLo	oral	100mg/kg (100mg/kg)	PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH	American Review of Respiratory Disease. Vol. 105, Pg. 206, 1972.
infant	TDLo	oral	91mg/kg (91mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Pediatrics. Vol. 95, Pg. 700, 1995.
man	LDLo	oral	116mg/kg (116mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA	Journal of Analytical Toxicology. Vol. 16, Pg. 57, 1992.
man	LDLo	oral	523mg/kg/17W- (523mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	JAMA, Journal of the American Medical Association. Vol. 176, Pg. 877, 1961.
man	TDLo	oral	39mg/kg/9D-I (39mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Southern Medical Journal. Vol. 75, Pg. 81, 1982.
man	TDLo	oral	100mg/kg/3W-C (100mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN SKIN AND APPENDAGES (SKIN): SWEATING: OTHER KIDNEY, URETER, AND BLADDER: OTHER CHANGES	American Review of Respiratory Disease. Vol. 106, Pg. 849, 1972.
man	TDLo	oral	430mg/kg (430mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Neurology. Vol. 20, Pg. 299, 1970.
mouse	LD50	intramuscular	137mg/kg (137mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	American Review of Tuberculosis. Vol. 65, Pg. 376, 1952.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	149mg/kg (149mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958.
mouse	LD50	oral	133mg/kg (133mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	American Review of Tuberculosis. Vol. 65, Pg. 376, 1952.
mouse	LD50	subcutaneous	125mg/kg (125mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 1225, 1961.
rabbit	LD50	intracrebral	> 12mg/kg (12mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rabbit	LD50	intramuscular	155mg/kg (155mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rabbit	LD50	intraperitoneal	147mg/kg (147mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rabbit	LD50	intravenous	94mg/kg (94mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	American Review of Tuberculosis. Vol. 65, Pg. 376, 1952.
rabbit	LD50	oral	250mg/kg (250mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 22, 1962.
rabbit	LD50	subcutaneous	135mg/kg (135mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rat	LD50	intramuscular	400mg/kg (400mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Therapie. Vol. 8, Pg. 62, 1953.
rat	LD50	intraperitoneal	335mg/kg (335mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952.
rat	LD50	intravenous	365mg/kg (365mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976.
rat	LD50	oral	1250mg/kg (1250mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976.
rat	LD50	subcutaneous	329mg/kg (329mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957.
women	TDLo	oral	12mg/kg/2D-I (12mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: ATAXIA	Neurology. Vol. 34, Pg. 703, 1984.
women	TDLo	oral	90200ug/kg/7D (90.2mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Pediatrics. Vol. 97, Pg. 782, 1996.
women	TDLo	oral	99300ug/kg (99.3mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	Pediatrics. Vol. 95, Pg. 700, 1995.
women	TDLo	oral	11250mg/kg (11250mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Anaesthesia. Vol. 47, Pg. 781, 1992.

 

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