CAS No.:55-22-1
Name: Isonicotinic acid
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 436mg/kg (436mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Pharmaceutical Chemistry Journal Vol. 11, Pg. 481, 1977. |
mouse | LD50 | intravenous | 5gm/kg (5000mg/kg) | Therapie. Vol. 23, Pg. 1343, 1968. | |
mouse | LD50 | oral | 3123mg/kg (3123mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Pharmaceutical Chemistry Journal Vol. 11, Pg. 481, 1977. |
rat | LD50 | oral | 5gm/kg (5000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Pharmaceutical Chemistry Journal Vol. 11, Pg. 481, 1977. |
Consensus Reports:
Reported in EPA TSCA Inventory.
SAFETY PROFILE:
Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: Xi
Risk Statements information:
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 2
Standards and Recommendations:
Analytical Methods:
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