CAS No.:73-78-9

TOXICITY DATA with REFERENCE：

1.		skn-rbt 3% MLD		AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 137 (1962),410.
2.		eye-rbt 3% MLD		AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 137 (1962),410.
3.		ivn-cld TDLo:60 mg/kg/1H		JTCTDW    Journal of Toxicology, Clinical Toxicology. 24 (1986),51.
4.		ivn-man TDLo:9 mg/kg/4H-C:CVS		DICPBB    Drug Intelligence and Clinical Pharmacy. 19 (1985),669.
5.		ivn-man TDLo:7143 µg/kg:BPR		CHETBF    Chest: The Journal of Circulation, Respiration and Related Systems. 61 (1972),682.
6.		imp-man TDLo:5714 µg/kg		CMAJAX    Canadian Medical Association Journal. 137 (1987),219.
7.		ipr-rat LD50:122 mg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 111 (1954),224.
8.		scu-rat LD50:570 mg/kg		RPOBAR    Research Progress in Organic Biological and Medicinal Chemistry. 2 (1970),299.
9.		ivn-rat LD50:21 mg/kg		RPOBAR    Research Progress in Organic Biological and Medicinal Chemistry. 2 (1970),299.
10.		orl-mus LD50:220 mg/kg		RPOBAR &nbs

Consensus Reports：

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

SAFETY PROFILE：

Poison by ingestion, intraperitoneal, intravenous, subcutaneous, intramuscular, and intratracheal routes. Human systemic effects: somnolence, respiratory depression, low blood pressure, cardiomyopathy including infarction, pulse rate increase. An experimental teratogen. Other experimental reproductive effects. A skin and eye irritant. An anesthetic. When heated to decomposition it emits very toic fumes of NO_x and HCl. Its hazard class is 6.1(b).
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Standards and Recommendations：

 

Analytical Methods：