CAS No.:58-27-5
Name: Menadione
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LDLo | intraperitoneal | 100mg/kg (100mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940. | |
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | National Technical Information Service. Vol. AD691-490, | |
mouse | LD50 | oral | 500mg/kg (500mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 125, 1940. | |
mouse | LD50 | subcutaneous | 138mg/kg (138mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942. | |
rabbit | LDLo | oral | 230mg/kg (230mg/kg) | VASCULAR: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 111, 1942. |
rat | LD50 | intraperitoneal | 75mg/kg (75mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
Consensus Reports:
Reported in EPA TSCA Inventory.
SAFETY PROFILE:
Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-43
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R43:May cause sensitization by skin contact.
Safety Statements: 26-36-37/39-24
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
S24:Avoid contact with skin.
WGK Germany: 3
RTECS: QL9100000
F: 8
Poison by ingestion, intraperitoneal, and subcutaneous routes. Experimental teratogenic effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Standards and Recommendations:
IDENTIFICATION: Conforms
ASSAY: 98.5 - 101.5%
RESIDUE ON IGNITION: 0.1% max
LOSS ON DRYING: 0.5% max
HEAVY METALS: 20ppm max
Analytical Methods:
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