CAS No.:108-67-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intraperitoneal	1303mg/kg (1303mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 227, 1954.
human	TCLo	inhalation	10ppm (10ppm)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI	Zeitschrift fuer Unfallmedizin und Berufskrankheiten. Revue de Medecine des Accidents et des Maladies Professionelles. Vol. 49, Pg. 265, 1956.
rat	LC50	inhalation	24gm/m3/4H (24000mg/m3)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(5), Pg. 15, 1979.

Consensus Reports：

 

SAFETY PROFILE：

Poison by inhalation. Moderately toxic by intraperitoneal route. Human systemic effects by inhalation: sensory changes involving peripheral nerves, somnolence (general depressed activity), and structural or functional change in trachea or bronchi. Reports of leukopenia and thrombocytopenia in experimental animals. A mild skin and eye irritant. A flammable liquid when exposed to heat or flame; can react vigorously with oxidizing materials. Violent reaction with HNO₃. To fight fire, use water spray, fog, foam, CO₂. Emitted from modern building materials ( CENEAR    Chemical and Engineering News. 69 (1991),22. ). When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Xi,N,F,T
Risk Statements: 10-37-51/53-39/23/24/25-23/24/25-11
10:  Flammable 
37:  Irritating to the respiratory system 
51/53:  Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
39/23/24/25:  Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
23/24/25:  Toxic by inhalation, in contact with skin and if swallowed 
11:  Highly Flammable  
Safety Statements: 61-45-36/37-16-7
61:  Avoid release to the environment. Refer to special instructions safety data sheet 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37:  Wear suitable protective clothing and gloves 
16:  Keep away from sources of ignition - No smoking 
7:  Keep container tightly closed  
RIDADR: UN 2325 3/PG 3
WGK Germany: 2
RTECS: OX6825000
F: 10: Keep under argon.
Hazard Note: Irritant/Flammable
HazardClass: 3
PackingGroup: III
HS Code: 29029080

Standards and Recommendations：

OSHA PEL: TWA 25 ppm
ACGIH TLV: TWA 25 ppm
DFG MAK: 20 ppm
DOT Classification:  3; Label: Flammable Liquid

Analytical Methods：

 Mesitylene (CAS NO.108-67-8) is prepared by distillation of acetone with sulfuric acid or by trimerization of propyne in sulfuric acid, which, in both cases, acts as a catalyst and dehydrating agent.