CAS No.:59122-46-2

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	10mg/kg (10mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 1055, 1993.
mouse	LD50	intramuscular	16mg/kg (16mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 11, Pg. 33, 1985.
mouse	LD50	intraperitoneal	70mg/kg (70mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Digestive Diseases and Sciences. Vol. 30, Pg. 142S, 1985.
mouse	LD50	oral	27mg/kg (27mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Digestive Diseases and Sciences. Vol. 30, Pg. 142S, 1985.
rat	LD50	intramuscular	19mg/kg (19mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 11, Pg. 33, 1985.
rat	LD50	intraperitoneal	40mg/kg (40mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Digestive Diseases and Sciences. Vol. 30, Pg. 142S, 1985.
rat	LD50	oral	81mg/kg (81mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 11, Pg. 33, 1985.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes of Misoprostol (CAS NO.59122-46-2): T
Risk Statements: 45-60-61-25-36/37/38 
R45: May cause cancer. 
R60: May impair fertility. 
R61: May cause harm to the unborn child. 
R25: Toxic if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 53-22-36/37/39-45 
S53: Avoid exposure - obtain special instructions before use. 
S22: Do not breathe dust. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 2
RTECS: UK8390000

Standards and Recommendations：

 

Analytical Methods：