CAS No.:98-92-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	2500mg/kg (2500mg/kg)		Pharmaceutical Chemistry Journal Vol. 20, Pg. 29, 1986.
mouse	LD50	intraperitoneal	2050mg/kg (2050mg/kg)		Radiation Research. Vol. 109, Pg. 479, 1987.
mouse	LD50	oral	2500mg/kg (2500mg/kg)		Drugs in Japan Vol. 6, Pg. 545, 1982.
mouse	LD50	subcutaneous	2gm/kg (2000mg/kg)		Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 48, 1946.
rat	LD50	oral	3500mg/kg (3500mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1390, 1986.
rat	LD50	subcutaneous	1680mg/kg (1680mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 19, 1946.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xi
Risk Statements: 36/37/38: Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection.
Nicotinamide rarely causes side effects, and is considered generally safe as a food additive, and as a component in cosmetics and medication.
 

Standards and Recommendations：

 

Analytical Methods：