CAS No.:2011-67-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	510mg/kg (510mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
mouse	LD50	oral	750mg/kg (750mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
rat	LD50	intraperitoneal	970mg/kg (970mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat	LD50	oral	970mg/kg (970mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat	LD50	subcutaneous	> 1gm/kg (1000mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.

Consensus Reports：

 

SAFETY PROFILE：

Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. An anticonvulsant and muscle relaxant. Related to diazepam. When heated to decomposition it emits toxic fumes of NO_x.

Standards and Recommendations：

 

Analytical Methods：